A mechanistically unique provides a variety of functionalized pyridine derivatives in fair to excellent yields. The scope of this reaction was studied with respect to the alkoxyallene, the nitrile, and the carboxylic acid.

Three-component synthesis of pyridines

Example (yield 50 %):

Three-component synthesis of highly functionalized pyridines

The authors suggested next mechanism:

Three-component synthesis of highly functionalized pyridines (mechanism)

Due to the 4-hydroxy group, these pyridine derivatives are suitable precursors for subsequent palladium-catalyzed reactions.

 

J. Dash, T. Lechel, H.-U. Reissig
Org. Lett., 5541 (2007) DOI