Published by admin on 18 Sep 2009
A mechanistically unique provides a variety of functionalized pyridine derivatives in fair to excellent yields. The scope of this reaction was studied with respect to the alkoxyallene, the nitrile, and the carboxylic acid.
Published by admin on 14 May 2008
The palladium-catalyzed four-component cross-coupling of imines, chloroformates, organostannane reagents, and carbon monoxide can be utilized to generate ketocarbamates (1), which are amenable to cyclization to generate imidazolones. Considering the mild conditions (1 atm of carbon monoxide, room temperature) and simple building blocks employed, this provides straightforward access to these heterocycles.
Published by admin on 17 Apr 2008
2,3,4,5-Tetrasubstituted pyrroles have been prepared with high regioselectivity by a formal cycloaddition of α-(alkylideneamino)nitriles and nitroolefins followed by elimination of HCN and HNO2. The reaction allows the convergent construction of the pyrrole ring in four steps from a nitroalkane and three aldehydes.
